|
KMID : 0616120100410030196
|
|
Korean Journal of Pharmacognosy
2010 Volume.41 No. 3 p.196 ~ p.203
|
|
|
Memory Enhancing Properties of the Ethanolic Extract of Black Sesame and its Ameliorating Properties on Memory Impairments in Mice
|
|
Kim Gong-Min
Kim Dong-Hyun
Park Se-Jin
Jung Ji-Wook
Ryu Gong-Hun
|
|
|
Abstract
|
|
|
|
Black sesame (Sesami semen nigrum) has been used to treat dizziness, earnoise, constipation in the traditional Chinese medicine. In the present study, we assessed memory enhancing properties of 70% ethanolic extract of black sesame (EBS70) and its ameliorating activities on learning and memory impairments induced by scopolamine. Drug-induced amnesia was made by scopolamine treatment (1 mg/kg, i.p.). Single EBS70 (200 mg/kg, p.o.) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks (P<0.05) and also reduced escape-latency on the Morris water maze task (P<0.05). In addition, EBS70 increased BDNF expression in hippocampus 4 h after its administration (P<0.05). These results suggest that EBS70 enhances learning and memory in normal state and attenuates amnesic state caused by cholinergic dysfunction.
|
|
|
KEYWORD
|
|
|
Black sesame, memory, passive avoidance task, Y-maze task, Morris water maze task
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|